Sunday, May 2, 2021

Getting Comfortable Shoes so you can walk more and have more energy

 

I am getting these for my friend Rob who helps me move a lot of heavy furniture. These shoes have rave reviews, so we'll see how he likes them. He has very wide feet and needs special shoes. According to the reviews, these are really good for people with wide feet.

Skechers Men's Go Walk Evolution Ultra-Impeccable Sneaker


Skechers Men's Go Walk Evolution Ultra-Impeccable Sneaker

Friday, April 30, 2021

Yes, you really should filter the water that comes out of your shower head!

 

My hair always feels way softer when I use a chlorine filter. I haven't used one for years, but am finally ordering this one. Will be posting more about why chlorine filtration is important, soon. 



[Upgraded] 18 Stage Shower Filter & Replacement, Hopopro High Output Universal Revitalizing Shower Head Filter Set Water Softener Remove Chlorine Fluoride Heavy Metals Sediments Impurities











Drinking MORE water

I am finally going to order some glass straws. I have found that I tend to drink a lot more, when I am using a straw. The only problem is that I don't fully trust drinking from metal or plastic straws, because I know they can leach toxic chemicals. Yes, really.


I am going to order these straws today, and will be adding more pictures of other bottles and cups and travel mugs, etc., that have motivated me to drink more water in the past. I just wish they would make glass versions of all of them, because that is the one type of material that I trust more than any other. 


Qisiewell Reusable Glass Drinking Straws - 14 x Straws 3 x Lengths 2 x Thickness 2 x Sisal Cleaning Brushes - Smoothie Straws for Milkshakes, Frozen Drinks, Bubble Tea, Fruit Juice





I also like my water to be cold, so if I don't have enough ice, I tend not to drink it. The ice cube trays I got from the dollar store are awful, they crack easily and I've wondered if I am ingesting plastic the last few months, because they're so badly cracked. Finally decided to invest in some higher quality ice trays. The reviews for these are impressive, so this is what I am getting.  Almost 13,000 (12,999 reviews) and a five star average, so I figure they must be halfway decent. 



Kitch Easy Release White Ice Cube Tray, 16 Cube Trays (Pack of 4) (4 Pack - 64 Cubes)



Kitch Easy Release White Ice Cube Tray, 16 Cube Trays (Pack of 4) (4 Pack - 64 Cubes)

Amazon'sChoicefor "ice cube tray"

0 Highlights found by Fakespot

List Price:$19.95 Details
Price:$10.95 FREE One-Day & FREE Returns
You Save:$9.00 (45%)



I am also getting some neopree sleeves because the water gets warm so fast where I live, in the summer. Going to try these out. 




Kvvdi 3 Pack 16 oz - 21 oz Neoprene Water Bottle Sleeve 16.9oz Portable Bottle Cooler Cover Holder Strap for Outdoor


Neoprene Insulated Sleeves Cup Cover Holder Idea for 20oz Tumbler Cup, 20oz YETI Rambler Ozark Trail Rtic, Starbucks Venti Cold (Only Cup sleeves) (Serape




Water Bottle Sleeve Neoprene Bottle Carrier Nylon Bottle Sleeve for 20 oz/550 ml Glass Water Bottle Great for Stainless Steel and Plastic Bottles, Sport and Energy Drinks



Cleaning with Eco-Friendly Disinfectants that won't harm you OR your pets

 Hypochlorous acid is THE... BEST... DISINFECTANT......... PERIOD.


For the last few years, this is pretty much the only disinfectant I use.

Why do I love this stuff so much? Let me count the ways....

Your body makes it, so it is biocompatible with you and not harmful to pets. 

I can make it super cheap from my machine

It disinfects extremely quickly

It doesn't leave a toxic residue on a surface

It saves me time.  I can spray just about anything and leave it, whereas if I used a traditional disinfectant, I'd have to take time to wipe it all up, to make sure my cats don't ingest it somehow. 

It's the safer and healthier option

You can learn more about this water on my facebook page, by CLICKING HERE.

This is what I use to spray it. These bottles are awesome. I already have two, but am ordering more.

Empty Amber Glass Spray Bottles with Labels (2 Pack) - 16oz Refillable Container for Essential Oils, Cleaning Products, or Aromatherapy - Durable Black Trigger Sprayer w/Mist and Stream Settings




Empty Amber Glass Spray Bottles with Labels (2 Pack) - 16oz Refillable Container for Essential Oils, Cleaning Products, or Aromatherapy - Durable Black Trigger Sprayer w/Mist and Stream Settings


Sunday, April 25, 2021

Can You Heal Your Own Teeth?

 I have been trying to heal my own teeth for a few years. Recently I felt a lot of pain in a cracked / chipped tooth in which half the filling portion fell out. I have been determined to heal it myself, and am making this post to explain why I think it's possible. I will be posting pictures of my own progress, soon.

I am ordering two products that I will be posting further down the page.  Tideglusib, plus an enzyme that eats up dental decay.




BRIX 3000




There are a few places that offer Tideglusib for sale, and I am going with this one: 

https://www.selleckchem.com/products/tideglusib.html


I realize I am taking a chance. I have no idea if this company is legit or not, but I do know that my late husband used to order stuff that worked (from a pharmacy in India) so I think it's worth taking a chance. I am going to just try out the smaller tube for now.  It does help me to see that they are BBB accredited. They didn't seem to have any reviews, but at least there weren't any BAD ones that I could find. 

https://www.bbb.org/us/tx/houston/profile/laboratory-research/selleck-chemicals-llc-0915-90021104 

BBB accredited since 4/27/2011. Laboratory Research in Houston, TX. See BBB rating, reviews, complaints, request a quote & more.

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Tideglusib

For research use only.

Catalog No.S2823 Synonyms: NP031112, NP-12

 22 publications

Tideglusib Chemical Structure

CAS No. 865854-05-3

Tideglusib (NP031112, NP-12) is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 2.

SizePriceStockQuantity 
USD 170In stock
USD 470In stock
USD 970In stock
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Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Batch:
Purity:
99.51 %

Choose Selective GSK-3 Inhibitors

NameGSK-3GSK-3αGSK-3βOthers
CHIR-99021 (CT99021) HCl
SB216763
AT7519CDK9/CyclinT,CDK5/p35,CDK2/CyclinA
CHIR-98014
TWS119
Tideglusib
SB415286
BIOTYK2,CDK5/p35,CDK2/CyclinA

Click to Expand This Table

Notes: 
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

DescriptionTideglusib (NP031112, NP-12) is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 2.
Targets
GSK-3β [1]
(Cell-free assay)
60 nM
In vitro

Tideglusib irreversibly inhibits GSK-3, reduces tau phosphorylation, and prevents apoptotic death in human neuroblastoma cells and murineprimary neurons. [1] Tideglusib (2.5 μM) inhibits glutamate-induced glial activation as evidenced by decreased TNF-α and COX-2 expression in rat primary astrocyte or microglial cultures. Tideglusib (2.5 μM) also exerts a potent neuroprotective effect on cortical neurons from glutamate-induced excitotoxicity as evidenced by significant reduction in the number of Annexin-V-positive cells in rat primary astrocyte or microglial cultures. [2]

Cell Data
 
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
SH-SY5YFunction assay10 uM1 hrsInhibition of GSK-3beta in human SH-SY5Y cells assessed as reduction in amyloid beta (25 to 35) -induced toxicity at 10 uM pre-incubated for 1 hrs before amyloid beta (25 to 35) addition and measured after 72 hrs post Abeta25-35 addition by MTT assay29208522
SH-SY5YFunction assay30 uM1 hrsInhibition of GSK-3beta in human SH-SY5Y cells assessed as reduction in amyloid beta (25 to 35) -induced toxicity at 30 uM pre-incubated for 1 hrs before amyloid beta (25 to 35) addition and measured after 72 hrs post Abeta25-35 addition by MTT assay29208522

Assay
MethodsTest IndexPMID
Western blot27501329
Growth inhibition assay27501329
In vivoTideglusib (50 mg/kg) injected into the adult male Wistar rats hippocampus dramatically reduces kainic acid-induced inflammation and has a neuroprotective effect in the damaged areas of the hippocampus. [2] Tideglusib (200 mg/kg, oral) results in lower levels of tau phosphorylation, decreased amyloid deposition and plaque-associated astrocytic proliferation, protection of neurons in the entorhinal cortex and CA1 hippocampal subfield against cell death, and prevention of memory deficits in APP/tau double transgenic mice. [3]

Protocol

Animal Research:[3]
- Collapse
  • Animal Models: Transgenic APPsw-tauvlw mice overexpressing human mutant APP and a triple human tau mutation.
  • Dosages: 200 mg/kg
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro

Batch:
DMSO (warmed with 50ºC water bath)8 mg/mL (23.92 mM)
WaterInsoluble
EthanolInsoluble
In vivoAdd solvents to the product individually and in order(Data is from Selleck tests instead of citations):
4% DMSO+Corn Oil
Click to purchase:Corn Oil
For best results, use promptly after mixing.
2.5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight334.39
Formula

C19H14N2O2S

CAS No.865854-05-3
Storage powder
 in solvent
SynonymsNP031112, NP-12
SmilesC1=CC=C(C=C1)CN2C(=O)N(SC2=O)C3=CC=CC4=CC=CC=C43

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosagemg/kgAverage weight of animalsgDosing volume per animalulNumber of animals
Step 2: Enter the in vivo formulation ()
DMSO   Tween 80 ddH2O
CalculateReset

Preparing Stock Solutions

ConcentrationVolumeMass1 mg5 mg10 mg
1 mM2.9905 mL14.9526 mL29.9052 mL
5 mM0.5981 mL2.9905 mL5.9810 mL
10 mM0.2991 mL1.4953 mL2.9905 mL
50 mM---

Bio Calculators

Molarity Calculator

MassConcentrationVolumeMolecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    I want to deliver S2823 via i.p. injection, can you suggest one?

  • Answer:

    This compound can be dissolved in 4% DMSO+corn oil at 2.5 mg/ml clearly. This is the highest concentration, since its solubility in DMSO is pretty low.

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I got the idea to take Alpha Lipoic acid to try to heal my tooth since I had learned how this stuff dramatically helps to repair a person's liver. It literally regenerates blood vessels. So I googled it to see if anyone else had used it, and this article popped up. Since I started taking it, it really helped!



Homesteading Self Sufficiency Survival

@HomesteadingSelfSufficiencySurvival Interest
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Alpha-Lipoic Acid - The Poor Man's Root Canal!
Alpha-lipoic acid is a naturally occurring vitamin-like nutrient produced in small quantities within the body for catalyzing reactions and recycling beneficial materials such as vitamin C and E. It is key involving the nervous, cardiovascular, immune, and detoxification systems of the body. Alpha-lipoic acid can pass the blood/brain barrier and penetrate tissues with somewhat ease, allowing it to kill infection extremely effectively in nearly all parts of the body - in this case the head, mouth and teeth. Pain experienced during varying stages of tooth decay is nearly always a sign of infection, even if only mild and will cause some very severe side effects if not handled rather quickly.
A highly effective solution, particularly for those who cannot afford the ridiculous dental costs in the United States, is to keep infection away in the meantime using alpha-lipoic acid. Known as the "poor man's root canal" for it's effectiveness in removing infection and pain in dental decay situations, it should be considered one of the first choices in dealing with dental problems such as pain and infection alongside the standard practices of cleanliness via brushing and using a mouthwash containing 3% hydrogen peroxide - preferably homemade.
Dosage
A typical effective dosage of alpha-lipoic for acute pain and infection is approx. 50mg every 3-4 hours for an average sized adult. However some use 100mg of alpha-lipoic every 4-6 hours.
And while most bottles of alpha-lipoic acid come with their own ingestion instructions and amounts, the practice is to typically take a higher dose (as high as 300mg) only once or twice in a 24 hour period. This is not effective in the case of acute dental infection or pain, since a regular supply is more effective against infection. Investing in a pill cutter or crusher and splitting or cutting the pills into proper increments for taking periodically is an excellent idea.
If only mild soreness is experienced or one is just keeping maintenance over the body here or there, a larger dose of 150mg 1-3 times daily is a more proper amount.
Alpha-lipoic acid can be taken when one is experiencing pain or discomfort from infection. It should only take approximately 1-2 days to rid the body of infection and therefore most or even all pain. Some take alpha-lipoic acid as a dietary supplement for it's benefits and we recommend the ingestion of alpha-lipoic acid every once in a while as a form of body cleanse.
You can find a good source of alpha-lipoic acid here:
Tablets-
Capsules-
An effective pill cutter for dosing can be found here:
11,000 Non GMO Heirloom Vegetable Seeds 30 Variety Pack: http://amzn.to/1RIEJaX
Visit our website for more natural remedies and survival info:
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Alpha-Lipoic Acid - The Poor Man's Root CanalAlpha-lipoic acid is a naturally occurring vitamin-like nutrient produced in small quantities within the...
Nov 8, 2020 — Conclusion alphalipoic acid treatment provided therapeutic effects on the ... Root canal contamination or exposure to lipopolysaccharide ...

People also ask

Web results

by O Molven · 2002 · Cited by 159 — Endodontics Periapical changes following root-canal treatment observed ... blind controlled study of alpha-lipoic acid (thioctic acid) therapy.
Address the root cause of oral health issues today. ... They told me that one tooth is dead and they wanted to do a root canal. I refused. I'm in to ... And recently I started taking Alpha Lipoic Acid 600mg and that helped even more. Any other ...
Alpha-Lipoic Acid – The Poor Man's Root Canal! ... The Potato Remedy for Tooth Abscess. Oral Health, Root Canals, Tooth Decay. Sandy JumperHolistic Cares.
by S Akman · 2013 · Cited by 64 — This study shows that ALA and Vit-C treatment provides therapeutic effects on inhibition of alveolar bone resorption and periodontal tissue destruction.
Missing: root ‎| Must include: root
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ffects of the Alpha‐Lipoic Acid therapy on experimentally induced apical periodontitis: A biochemical, histopathological and micro‐CT analysis

Authors:

Abstract

Aim To investigate the possible therapeutic effects of alpha‐lipoic acid (ALA) in a model of chronic apical periodontitis in rats by analysing biochemical, histopathological and micro‐CT parameters. Methodology The study was approved by the Animal Ethics Committee of the Near East University. Thirty‐two Wistar rats were divided into four groups of eight rats each: Control Group; ALA Group; AP Group; AP + ALA Group. In the AP and AP + ALA groups, the pulp chambers of the mandibular first molars were surgically exposed and were left open to the oral environment for 4‐weeks to allow the establishment of periapical lesions. The rats in the Control and AP groups were treated intraperitoneally with saline solution (with a daily dose of 100 mg kg⁻¹, for 28 days after periapical lesion induction). The rats in the ALA and AP + ALA groups were treated intraperitoneally with ALA (with a daily dose of 100 mg kg⁻¹, for 28 days after periapical lesion induction). After decapitation, the trunk blood was collected for the assessment of biochemical parameters. The mandibles were surgically removed and dissected for histopathologic analysis and further scanned with micro‐CT. Groups of data were compared with a two‐way analysis of variance (two‐way anova) followed by Sidak's multiple comparison tests. Values of P < 0.05 were regarded as significant. Results TNF‐α, IL‐1β, MMP‐1, MMP‐2 levels were significantly lower in AP + ALA group compared with AP group (P < 0.05). There was a significant difference between the AP and AP + ALA groups according to assessment of the inflammatory scores (P < 0.05). The periapical inflammatory infiltrates were significantly more severe (P < 0.05) in the AP group. The AP + ALA group exhibited lower values both in terms of surface area and volume of resorption cavities than the AP group and this difference was significant (P < 0.05). Conclusion alpha‐lipoic acid treatment provided therapeutic effects on the inhibition of periapical bone loss.